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A Guide To Porphyria SAFE & UNSAFE DRUGS
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Thought to be safe |
Might be associated with porphyria
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Acetomenophen |
Amiodarone |
Aminoglycosides |
Barbiturates |
| Aspirin | Amitryptyline |
| Atropine | Bromocriptine |
Chloral hydrate |
Carbamezepine |
Chlorpromazine |
Chlorpropamide |
Cimetidine |
Chloroquine |
Dicumarol |
Cocaine |
| Digoxin | Danazol |
Epinephrine |
Diclofenac |
Fentanyl |
Diphenhydramine |
Gabapentin |
Ergot preparations |
Glucocorticoids |
Estrogen compounds |
Heparin |
Erythromycin |
Ibuprofen |
Ethanol excess |
Insulin |
Eucalyptol (in mouth wash) |
Labetalol |
Griseofulvin |
Lithium |
Imipramine |
Magnesium |
Meprobamate |
| Methotrexate | Methyldopa |
Methylphenidate |
Minidoxil |
Naproxen |
Nikethimide |
Narcotic analgesics |
Nitrofurantoin |
Neostigmin |
Oral contraceptives |
Nitrous oxide |
Phenytoin & Dilantin |
Oxezepam |
Primidone |
Penicillins |
Progesterone derivatives |
Phenothiazines |
Rifampin |
Propanalol |
Spironolactone |
Propoxyphene |
Sulfonamides |
Tetracyclines |
Tamoxifen |
Thiouracil |
Theophylline |
Thyroxin |
Tetracyclines |
Vitamins A,B,C,D & E |
Tolbutamide |
| Trazadone | |
| Trimethoprim | |
| Valproic acid | |
The potential for a drug inducing an acute attack of porphyria is based primarily on clinical experience although some tests have been carried out on animals with experimental porphyria. This list must serve as a guide only since individual patient reactions to individual drugs is complex and unpredictable. For example, the birth control pills are usually contraindicated in AIP but they are often prescribed to prevent the onset of the acute attacks which are directly related to the menstrual cycles.
Canadian Association for Porphyria • Box 1206 Neepawa, Manitoba, Canada R0J 1H0 Telephone/Fax: (204) 476-2800 |