Canadian Porphria Foundation

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A Guide To Porphyria

SAFE & UNSAFE DRUGS
IN
Acute Intermittent Porphyria, Variegate porphyria and Coproporphyria

that are commonly prescribed by Canadian physicians

Thought to be safe

Might be associated with porphyria
Acetomenophen
Amiodarone

Aminoglycosides

Barbiturates
Aspirin
Amitryptyline
Atropine Bromocriptine
Chloral hydrate
Carbamezepine
Chlorpromazine
Chlorpropamide
Cimetidine
Chloroquine
Dicumarol
Cocaine
Digoxin Danazol
Epinephrine
Diclofenac
Fentanyl
Diphenhydramine
Gabapentin
Ergot preparations
Glucocorticoids
Estrogen compounds
Heparin
Erythromycin
Ibuprofen
Ethanol excess
Insulin
Eucalyptol (in mouth wash)
Labetalol
Griseofulvin
Lithium
Imipramine
Magnesium
Meprobamate
Methotrexate Methyldopa
Methylphenidate
Minidoxil
Naproxen
Nikethimide
Narcotic analgesics
Nitrofurantoin
Neostigmin
Oral contraceptives
Nitrous oxide
Phenytoin & Dilantin
Oxezepam
Primidone
Penicillins
Progesterone derivatives
Phenothiazines
Rifampin
Propanalol
Spironolactone
Propoxyphene
Sulfonamides
Tetracyclines
Tamoxifen
Thiouracil
Theophylline
Thyroxin
Tetracyclines
Vitamins A,B,C,D & E
Tolbutamide
  Trazadone
  Trimethoprim
  Valproic acid
   
   

The potential for a drug inducing an acute attack of porphyria is based primarily on clinical experience although some tests have been carried out on animals with experimental porphyria. This list must serve as a guide only since individual patient reactions to individual drugs is complex and unpredictable. For example, the birth control pills are usually contraindicated in AIP but they are often prescribed to prevent the onset of the acute attacks which are directly related to the menstrual cycles.

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Canadian Association for Porphyria • Box 1206  Neepawa, Manitoba, Canada R0J 1H0
Telephone/Fax: (204) 476-2800